A PREDICTIVE PLATFORM FOR HUMAN LUNG PHARMACOKINETICS OF INHALED BIOTHERAPEUTIC PROTEINS

Abstract

Protein-based medications are deposited, absorbed, distributed, maintained, and removed from the respiratory system using a predictive tool for human lung pharmacokinetics (PK) of inhaled biotherapeutic proteins. To precisely forecast drug absorption and distribution, the platform makes use of lung physiology, aerosol deposition characteristics, physiologically based pharmacokinetic (PBPK) models, and protein-specific characteristics including molecular weight, stability, and permeability. This approach minimizes animal research and streamlines human preclinical application. It is possible to enhance the simple formulation design, breathing device, and dosing schedule. This platform speeds up the creation of safe, efficient, and tailored inhaled biotherapeutic proteins for pulmonary infections, COPD, asthma, and cystic fibrosis.